Health Risks

Gout

Gout is caused by a combination of genetic and environmental factors.

DEMO Result

Based on your genetics, your personal predicted risk is

7.24


Your risk for Gout also depends on other factors, including lifestyle and genetic variants not covered by this test.

The population risk for Gout is 7.7

How To Use This Test


This test SHOULD NOT be used to diagnose Gout or any other health conditions.


Please talk to a healthcare professional if you have a family history, if you think you might have this condition or if you have any concerns about your results.

Intended Uses

This predicted personal genetic risk merely considers the genetic/genotype effect towards the disease in an individual without taking into account the environmental factors such as lifestyles, diet and their environment

This result is based on the SNPs (single nucleotide polymorphism) that are associated with Gout.

Read more


Limitations

The results of this test do not diagnose Gout or related conditions. This should not be used as a diagnostic tool.

This result does not include all possible variants or genes associated with Gout.

This result is limited to existing scientific research.

Lifestyle & Other Risk Factors Can Influence The Risk of Developing Gout

Genetics are NOT the only risk factor for Gout.

Gout is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.

The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Gout.

Alcohol
Alcohol

Having excessive alcohol use increases the risk of developing gout.

Weight
Weight

Being overweight and obese increases the risk of developing gout.

Diet
Diet

Having a diet high in certain high-purine foods increases the risk of developing gout.

Suggested Lifestyle Changes

Dietary Recommendations

1

Folate intake and coffee consumption can reduce the risk of gout.

2

Having high consumption of meat, seafood, food high in fructose (sugar) and sweetened soft drink can increase the risk of gout.

3

Look into avoiding/reducing food with high levels of purines (which will be broken down and contribute to high levels of uric acid). Some examples of high purine food are meat (liver and kidney) and seafood (anchovies and sardine).

4

Consumption of vegetables and low-fat or non-fat dairy products may help to reduce the frequency of flareups in gout.

5

Reducing alcohol consumption can help reduce the risk of developing gout.

What Is Gout
and How Can It Affect You

What is Gout

Gout is a form of arthritis caused by high levels of uric acid in the bloodstream. The excess uric acid forms needle-like crystals (urate) in the joints, which accumulates and causes inflammation in the joints. This can cause sudden and severe pain, swellings and redness.

Multiple genetic variations, each with a small effect, likely combine to increase the risk of developing gout. Most of the known genes play a role in transporting urate. Many gout-associated genes play a role in releasing urate into the urine if levels are too high or reabsorbing it back into the bloodstream if more is needed in the body. Other associated genes are involved in transporting or breaking down sugars or transporting other small molecules.

Symptoms Of Gout

The symptoms of gout usually happens all of a sudden and often at night. The signs and symptoms include:

1. Intense joint pain
Intense pain in or around the affected joint. Any joint can be affected by gout, but it usually affects joints towards the ends of the limbs, such as the toes, elbows, wrists, ankles, knees and fingers. Symptoms of gout can develop over a few hours and can last for three to 10 days. As gout progresses, it may lead to limited range of motion and the patient might not be able to move the affected joints normally.

2. Inflammation and redness
This includes swelling and redness around the affect joint or joints

3. Limited range of movement
Over time as the disease progress, it may lead to limited range of motion and the patient might not be able to move the affected joints normally.

How Does Gout Affect You?

When the body breaks down purines (found in food), uric acid is formed. It will be eliminated by the kidney as urine. In some cases, the body overproduces uric acid or makes normal amount, however the kidney is unable to efficiently eliminate it from the body. There will be high levels of uric acid in the body, which leads to the formation of crystals. Over time, the joint space can be irreversibly damaged, leading to chronic pain and disability with grossly deformed joints.

If you have a family history of this condition or think you have the symptoms, consult with a healthcare professional.

Understanding Your Results

How Is Your Genetic Risk Calculated?

Your genetic risk assessment is

7.24

Genes tested

This result is calculated based on the following SNPs (single nucleotide polymorphism) that are associated with Gout.

GenesYour GenotypeWhat It Means
GCKR_exon15CCTypical
ABCG2GGTypical

Limitations

This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.

This result is limited to existing scientific research.

Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.