Nutrigenomics Folate Requirement

Based on your genetics, your genetic predisposition for Folate Requirement is

High
Low
Normal
High

What does this mean?

Likely to have increased risk of folate deficiency Your genotype is associated with reduced enzyme activity and lower serum folate level. You should consume at least 400 mcg of folate a day, but not exceeding 1000 mcg/day (RNI for Malaysia).

How Is Your Genetic Risk Calculated?

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Folate Requirement.

Genes
Your Genotype
What it means?
Genes: MTHFR
Your Genotype: CT
What it means? Reduced enzyme activity
!

Limitations

This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Folate Requirement?

Folic acid (also known as folate or vitamin B9) is an essential nutrient from the B complex group of vitamins. Folate plays an important role in synthesis, repair and methylation of DNA, production of healthy red blood cell, cell division, as well as mental and emotional health.

Folate is especially needed during pregnancy and infancy, to reduce the risk of birth defects of the brain and spine. Folic acid deficiency is often associated with elevated levels of homocysteine, a naturally occuring amino acid produced using methylation process.

How It Affects Your Body

Folate plays an important role in the synthesis, repair, and methylation of DNA, production of healthy red blood cells, cell division, as well as mental and emotional health. Folate is especially needed during pregnancy and infancy, to reduce the risk of birth defects of the brain and spine. Folic acid deficiency is often associated with elevated levels of homocysteine which increases the risk of artery damage and coronary artery disease.

Symptoms

Alcohol

Chronic alcohol consumption has been shown to decrease folate absorption and increase folate excretion. This can contribute to low serum folate levels.

Diet

A diet low in leafy green vegetables, beans, citruses, and meat can contribute to low serum folate levels.

Pregnant / Breastfeeding

Serum folate is rapidly utilized due to fetal growth and during breastfeeding. This increases the risk of folate deficiency.

Dialysis

Studies have shown dialysis depletes serum folate levels by up to 37%.

Medication

Diabetic individuals who take metformin may have decreased folate absorption - which increases the risk of folate deficiency.

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Consume folate rich food to maintain sufficient folate intake. Leafy greens, organ meats, citrus fruit juices, legumes, nuts, and fortified foods, such as enriched bread and cereals are good sources of folate.
  2. The bioavailability of folic acid is assumed to be 100% when taken as a supplement, while folic acid in fortified food is estimated to have about 85% bioavailability.
  3. Bioavailability of food sources varies widely between 25-50%, due to certain compounds in foods such as whole grains and legumes, which inhibit folate absorption. Thus, naturally occurring folates are not as bioavailable as folic acid supplements.

Supplement Recommendations:

    Result Explanation Recommendations:

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