Weight Management Metabolic Circadian Rhythm Disorder

Based on your genetics, your genetic predisposition for Metabolic Circadian Rhythm Disorder is


What does this mean?

 Your genotype indicates higher difficulties to achieve desired weight loss due to the metabolic circadian rhythm.

How Is Your Genetic Risk Calculated?

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Metabolic Circadian Rhythm Disorder.

Your Genotype
What it means?
Genes: CLOCK
Your Genotype: TC
What it means? More likely to be obese compared to typical genotype (TT) people


This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Metabolic Circadian Rhythm Disorder?

The circadian rhythm plays a vital role in regulating a wide variety of physiological events such as sleeping and waking, as well as metabolism. Lifestyle has a great impact on the circadian system, and therefore on the body internal organisation of physiological and biochemical processes that regulates various behaviours. Disruption of the circadian clock is strongly linked to metabolic imbalance. In this modern era, lifestyles are increasingly becoming more flexible in terms of when to eat, sleep, socialise, and exercise. This flexibility may be associated with the increased risk of both mental and metabolic disorders such as diabetes, obesity, and heart diseases due to inconsistent meal times, unhealthy diets, as well as lack of sleep and physical activity. However, the effects of diet and lifestyle on weight gain or loss may differ across individuals as genetic variation is one of the key factors in regulating metabolic circadian rhythm.

How It Affects Your Body

The circadian rhythm is present in every cell in our body. A consistent rhythm allows our body to function optimally.

Disruption will affect our energy cycle, causing sudden fluctuations in energy. We may feel this through a short burst of productivity followed by prolonged tiredness throughout the day. A healthy cycle would also allow us to acquire quality sleep at specific times at night. Disruption will cause sleep issues such as insomnia, late or early sleep and waking times, and disrupted sleep.

Finally, a healthy cycle helps us maintain a healthy body composition. Disruptions will also lead to muscle mass loss and fat gain, especially visceral fat. Even hormonal balance is affected, which can lead to increased stress levels, depression, skin disorders, and more.

How It Affects Your Body

The circadian rhythm system is regulated by a central clock in the brain and secondary clocks in other organs. The master clock in the brain is set by light and determines the overall diurnal or nocturnal preference.

A nocturnal person tends to be active at night while a diurnal prefers the morning. These preferences affect the sleep-wake cycle. Circadian clocks are also important in maintaining metabolic health.

Studies have shown that the circadian clocks in skeletal muscles not only affects muscle mass and strength, but also fat and carbohydrate breakdown.

Symptoms of Irregular Circadian Rhythm

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Adopt feeding regimens with a timing cue to reset the circadian clock (e.g. restricted feeding, calorie restriction, and intermittent fasting), which may also lead to better health.

Lifestyle Recommendations:

  1. Cultivate good sleep hygiene by refraining from drinking coffee or tea in the evening and avoid taking long naps in the afternoon.
  2. Set a consistent time for sleeping and waking up, usually 8 hours on average.
  3. Travelling to a country with a different time zone can affect one? body clock. Plan ahead on the sleep schedule you need before, during and after the trip to minimise the effect of jet lag.

Result Explanation Recommendations:

    Result Explanation Recommendations:

    1. Regular physical activity should be part of your health regime to maintain overall health.
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