Health Risks Coronary Artery Disease

Based on your genetics, your genetic predisposition for Coronary Artery Disease is


What does this mean?

 Your genotypes indicate that you have normal risk for Coronary Artery Disease.

How Is Your Genetic Risk Calculated?

Your genetic risk assessment is


This result is based on the SNPs(single nucleotide polymorphism)that are associated with Coronary Artery Disease.

Your Genotype
What it means?
Genes: IRS1
Your Genotype: CC
What it means? Increased risk
Genes: ANRIL
Your Genotype: GG
What it means? Typical
Genes: FMN2
Your Genotype: TT
What it means? Increased risk
Genes: CDH13_intron4
Your Genotype: GT
What it means? Increased risk
Genes: ABO
Your Genotype: TT
What it means? Typical
Genes: LPA
Your Genotype: TT
What it means? Typical
Genes: SORT1
Your Genotype: AA
What it means? Increased risk
Genes: LDLR_intron30
Your Genotype: GG
What it means? Increased risk


This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Coronary Artery Disease?

Coronary artery disease (CAD) is the most common heart disease.

CAD develops when the coronary arteries (major blood vessel that supplies blood, oxygen and nutrients to the heart) thickened and narrowed. This is due to plaque (cholesterol-containing deposits) build-up in the inner walls of the arteries. This narrows your coronary arteries, decreasing blood flow to your heart. When the heart muscle doesn’t get enough blood and oxygen, it can lead to chest pain and heart attack. A complete blockage can cause a heart attack.

Genetic and environmental factors, such as diet, smoking, and physical inactivity play a role in the development of CAD.

Heart disease is the leading cause of death in the developed world, responsible for about 1 in every 5 deaths. It is also the leading cause of mortality in Malaysia, which accounted for 13.2% death in 2016.

How does coronary artery disease affect your body?

The thickening artery wall (due to plagues) gradually causes the narrowing of the artery, which can eventually result in a restriction of blood flow. Stable plaques do not rupture but limit blood flow to supply oxygen to tissues, and usually lead to chest pain. Unstable plaques are prone to erosion or rupture, and may cause the formation of blood clots in the artery.

When blood clots happen, it can obstruct blood flow, increasing the likelihood of complete blockage of the artery. Plaque rupture with temporary or incomplete blockage of artery results in reduced blood flow to the heart, while plaque rupture with complete blockage of artery and tissue death causes heart attack (myocardial infarction).

What are the symptoms of coronary artery disease?

Risk Factors Can Influence The Risk of Developing Coronary artery disease

Genetics are NOT the only risk factor for Coronary Artery Disease.
Coronary Artery Disease is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.
The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Coronary Artery Disease.


Being post-menopausal for women and being older than 45 for men increases the risk of developing coronary artery disease.


Having diabetes increases the risk of developing coronary artery disease.

Blood Pressure

Having high blood pressure increases the risk of developing coronary artery disease.

Cholesterol Levels

Having high LDL (bad) cholesterol and low HDL (good) cholesterol increases the risk of developing coronary artery disease.

Family History

Having a family history of coronary artery diseases increases the risk of developing coronary artery disease.

Suggested Lifestyle Changes

Dietary Recommendations:

  1. A diet low in fat (<10% of total amount of calories), low in salt, low in cholesterol (<300 mg/day), low in calories, and high in fiber (>20 g/day) can help to reduce the risk of coronary artery disease.
  2. Limit the intake of butter, lard (when cooking), baked goods and sugary beverages.
  3. Consume low fat milk and dairy products, lean meat, aim to use salt-free seasoning.
  4. Reduce having canned food which have high amount of salt.
  5. Consume more nuts such as almonds, hazelnuts, walnuts, pistachios, pine nuts, cashews, pecans, macadamias, and Brazil nuts as they are beneficial in preventing cardiovascular heart diseases.
  6. Soybeans are a good source of fiber, iron, calcium, zinc, and B vitamins, and the consumption of soy product is also associated with reduced risk of coronary heart disease.
  7. Diets which are high in raw vegetables and fruits can also help to reduce coronary artery disease risk. If possible limit or avoid fried and breaded vegetables, canned vegetables which are in high in sodium, frozen/canned fruits with added sugar.

Lifestyle Recommendations:

  1. Stop smoking to reduce the risk of coronary artery disease. Smoking causes excessive oxidative and tissue damage to the vascular system. This can dramatically accelerate plaque buildup and CAD.
  2. Avoid excessive alcohol consumption to reduce the risk of CAD progression. Avoid exceeding more than 2 servings of alcoholic beverages per day. However, studies have shown light alcohol consumption to be beneficial in stimulating a healthy heart function. A serving of wine a day is high in resveratrol, a potent antioxidant that can preserve healthy heart function.
  3. Aim to do more physical activities to increase cardiovascular and respiratory performance as well as improve body composition.
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