Health Risks Atopic Dermatitis/Eczema

Based on your genetics, your genetic predisposition for Atopic Dermatitis/Eczema is

Normal
Low
Normal
High

What does this mean?

 Your genotype indicates that you have a typical risk for atopic dermatitis/eczema.

How Is Your Genetic Risk Calculated?

Your genetic risk assessment is

21.66

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Atopic Dermatitis/Eczema.

Genes
Your Genotype
What it means?
Genes: TNFRSF6B/ZGPAT
Your Genotype: AG
What it means? Increased risk
!

Limitations

This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Atopic Dermatitis/Eczema?

Eczema is a skin disease that causes red, dry, irritated and skin patches to form. Atopic dermatitis (AD) is a common form of eczema that can become severe and long-lasting. It also tends to flare periodically. This type of skin condition makes your skin appear red and itchy due to inflammation in the outer layer of the skin. AD is a complex genetic disease arising from several gene-gene and gene-environment interactions. It is common in children but can occur at any age. AD may be accompanied by asthma or hay fever. Around 50-75% of all children with early-onset atopic dermatitis are sensitised to one or more allergens (proteins that trigger an allergic reaction), such as food allergens, house dust mites, or pets, whereas those with late-onset atopic dermatitis are less often sensitised.

How It Affects Your Body

The real cause and pathway of atopic dermatitis/Eczema are still unknown, but evidence suggests that AD is caused by genetic variation, environmental factors, and immune dysfunction. In a healthy condition, the skin remains moisturised and prevents irritants, bacteria and allergens to cross the skin barrier. Eczema is associated with genetic variation, therefore any genetic changes would affect the skin protection barrier, which in turn, allows the environmental factors to cross the skin protective barrier.

How may atopic dermatitis/Eczema affect your body?

The real cause and pathway of atopic dermatitis/Eczema are still unknown, but evidence suggests that AP is caused by genetic variation, environmental factors, and immune dysfunction. In a healthy condition, the skin remains moisturised and prevents irritant, bacteria and allergen to cross the skin barrier. Eczema is associated with genetic variation, therefore any genetic changes would affect the skin protection barrier which in turn, allows the environmental factors to cross the skin protective barrier.

Treatment

Signs and Symptoms

Treatment of Eczema

Signs and Symptoms

Risk Factors Can Influence The Risk of Developing Atopic dermatitis/eczema

Genetics are NOT the only risk factor for Atopic Dermatitis/Eczema.
Atopic Dermatitis/Eczema is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.
The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Atopic Dermatitis/Eczema.

Triggering Factors

Other Allergy

Food (Soy milk, eggs, shellfish etc)

Other Allergy

Environmental Factors (Air pollution, warm and high sun exposure, newly painted building with natural ventilation)

Other Allergy

Physical irritants (Nylon, wool clothing, soaps, detergents, chemical reagents, sweats)

Other Allergy

Aeroallergen (Pollen, house dust, indoor house mites, unfamiliar pets).

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Avoid junk food and dairy products, for example cow? milk, eggs, peanuts, wheat, soy, nuts, and fish, which are responsible for >90% of food allergies among children.
  2. Increase the consumption of food that are rich in carotenoids, flavonoids, vitamins and minerals. For example: carrots, yams, sweet potatoes, papaya, watermelon, cantaloupe, mangoes, spinach, kale, bell peppers, oranges, tea, and berries.

Supplement Recommendations:

  1. Vitamin D supplement is used to prevent and treat Eczema
  2. Probiotics supplement (Suitable from age 2-4 years of high risk allergy cohort for prevention)
  3. Quercetin (Natural antihistamine) (quercetin rich food such as leafy vegetables, red wine etc)
  4. No significant difference for use of supplements

Lifestyle Recommendations:

  1. Use skin moisturising creams or emollients daily to reduce dryness of your skin.
  2. Avoiding long, hot baths can prevent skin dryness. However, an emollient should be applied directly after a bath to secure a moist epidermis and augment the skin barrier function.
  3. Avoid long exposure to common eczema irritants like nickel, cigarette smoke, soaps, detergents, fragrances, antibacterial ointments, household disinfectants, glues, etc.
  4. Emotional stress can also cause atopic dermatitis
  5. be sure to look for ways to manage stress.
  6. Reduce contact with grass and sand.
  7. Avoid long durations of exposure to chlorinated pools when swimming.
  8. Overheating and sweating can cause irritation to skin barrier.

Exercise Recommendations:

  1. Avoid harsh fabrics like polyester.
  2. Carry a towel to wipe off sweats to prevent skin irritation.
  3. Drink plenty of water before, during exercise and after to avoid dry skin.
  4. Avoiding long, hot baths can further prevent skin dryness. However, when a bath is taken, an emollient should be applied directly after it to secure a moist epidermis and augment the skin barrier function.
  5. Apply emollient if you want to swim in a pool with chlorine disinfectant. You should also take a shower immediately after swimming as it acts as a protection layer for the skin.
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