Health Risks Familial Hypercholesterolemia

Based on your genetics, your genetic predisposition for Familial Hypercholesterolemia is


What does this mean?

Likely to have typical risk of Familial Hypercholesterolaemia Your genotypes indicate that you have normal risk for Familial Hypercholesterolemia.

How Is Your Genetic Risk Calculated?

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Familial Hypercholesterolemia.

Your Genotype
What it means?
Genes: LDLR.1
Your Genotype: CC
What it means? Typical
Genes: APOB_exon26
Your Genotype: GG
What it means? Typical
Genes: LDLR.2
Your Genotype: GG
What it means? Typical
Genes: LDLR_exon9
Your Genotype: GG
What it means? Typical
Genes: LDLR.3
Your Genotype: CC
What it means? Typical
Genes: LDLR.4
Your Genotype: TT
What it means? Typical
Genes: LDLR_exon12
Your Genotype: GG
What it means? Typical
Genes: LDLR_exon2
Your Genotype: CC
What it means? Typical


This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Familial Hypercholesterolemia?

Familial hypercholesterolemia (FH) is a defect that is passed down through families. It causes raised levels of “bad” cholesterol called LDL (low density lipoprotein). High levels of LDL in the body can contribute to heart related complications.

Since it is an inherited condition (from birth), it can cause heart attack at early stages. Normally, cholesterol levels tend to increase with age. However, people with FH have high levels of LDL even from a very young age, and it continues to go higher as they age.

FH causes a defect where the body is unable to remove the LDL from the bloodstream efficiently. When there is too much cholesterol in the blood, it can cause buildup of plaque (deposits) in the artery (blood vessels connecting to the heart). These plaques can harden over time and cause the blood vessels to become narrow, limiting the supply of oxygen-rich blood to other organs in the body. This can lead to heart attack.

How can familial hypercholesterolemia affect you?

Familial Hypercholesterolemia causes:

Do you have symptoms of high cholesterol levels?

Risk Factors Can Influence The Risk of Developing Familial hypercholesterolemia

Genetics are NOT the only risk factor for Familial Hypercholesterolemia.
Familial Hypercholesterolemia is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.
The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Familial Hypercholesterolemia.


In general, eating a healthy diet, maintaining a healthy weight, engaging in physical activity, and avoiding smoking can reduce the risk for heart disease.


Smoking increases the risk for heart disease. Exposure to secondhand smoke, including smoke from a burning cigarette and smoke exhaled by smokers, also increases the risk for heart disease.


In general, the risk for heart disease increases as a person gets older. With age, blood vessels become less flexible, which can impede blood flow to the heart. Also, deposits called plaques can build up over time along blood vessels and restrict blood flow to the heart.

High Blood Pressure

Chronic high blood pressure increases the risk for heart disease. High blood pressure puts excess strain and increased workload on the heart and blood vessels, which can damage them over time.

Family History

Parents, siblings, and children of an individual with early heart disease (younger than 55 years in men and younger than 65 years in women) have a higher chance of developing heart disease themselves.

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Increase intake of vegetables, fruit, non-fat dairy, beans, tree nuts, fish and lean meats should be encouraged
  2. Cut down consumption of saturated fat (fatty beef, lamb, cheese, butter) to less than 7% of calories. Instead take polyunsaturated fats, protein or carbohydrates.
  3. Avoid trans fats (processed food)
  4. Moderate consumption of alcohol
  5. Consider adding plant stanols which are naturally occurring plant chemicals that block cholesterol absorption in the the digestive system, therefore lowering the levels of LDL (bad) cholesterol in the blood. Plant stanols can be found in wheat germ, wheat bran, peanuts, vegetable oils (olive oil), almonds and Brussels sprouts. Certain dairy products have added plant stanols in it which include fortified milk, spreads, yoghurts and yoghurt drinks

Lifestyle Recommendations:

  1. Aim to have more than 150 minutes of moderate-intensity (brisk walking, doing housework) physical activity or 75 minutes of vigorous (running, fast swimming, jogging, aerobics) activity each week. This will help in increasing HDL level and lowering LDL level.
  2. Stop smoking
  3. Maintain a healthy weight
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