Health Risks Non-Alcoholic Fatty Liver Disease

Based on your genetics, your genetic predisposition for Non-Alcoholic Fatty Liver Disease is

Normal
43.54
0%
25.5
76.5
100%

What does this mean?

 Your genotypes indicate that you have normal risk for Non-Alcoholic Fatty Liver Disease.

How Is Your Genetic Risk Calculated?

Your genetic risk assessment is

43.54

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Non-Alcoholic Fatty Liver Disease.

Genes
Your Genotype
What it means?
Genes: PNPLA3
Your Genotype: CG
What it means? Increased risk
Genes: SOD2
Your Genotype: TT
What it means? Increased risk
Genes: KLF6
Your Genotype: GG
What it means? Increased risk
!

Limitations

This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Non-Alcoholic Fatty Liver Disease?

Non‐alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. NAFLD refers to the accumulation of excessive fats in liver cells, a condition known as steatosis and it is not due to excess alcohol consumption.

The prevalence of NAFLD is up to 30% in developed countries and nearly 10% in developing nations, making NAFLD the most common liver condition in the world.

NAFLD is strongly associated a with a number of metabolic risk factors including increased abdominal fat, poor ability of the body to use the hormone insulin or a condition better known as insulin resistance, high blood pressure and high blood levels of triglycerides, a type of fat and most significantly, obesity.

Over time, some people in these conditions (obesity, metabolic syndrome) can develop inflammation (swelling) of the liver. In some people, this inflammation can cause injury to the liver cell resulting in scarring of the liver tissue. Over years as more and more scar tissue begins building up, the liver will begin to harden a condition known as cirrhosis. This is considered a severe stage of the disease and it will only progress further causing liver failure or it increases the risk of developing liver cancer (Hepatocellular Carcinoma).

How can non-alcoholic fatty liver disease affect you?

NAFLD causes central obesity (abdominal fat) or diabetes. NAFLD patients are at increased risk of liver-related as well as heart -related mortality, and NAFLD is rapidly becoming the leading indication for liver transplantation.

NAFLD is a silent disease as it hardly shows any symptoms at an early stage. However when you start to experience pain on the right upper side of the abdomen and yellowing of the skin and eyes due to increase level of liver enzymes in the blood, the disease unfortunately has progressed into a much severe stage.

Symptoms of NAFLD

Risk Factors Can Influence The Risk of Developing Non-alcoholic fatty liver disease

Genetics are NOT the only risk factor for Non-Alcoholic Fatty Liver Disease.
Non-Alcoholic Fatty Liver Disease is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.
The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Non-Alcoholic Fatty Liver Disease.

Cholesterol Level

Having high triglyceride levels in the blood increases the risk of developing NAFLD.

Blood Pressure

Having high blood pressure increases the risk of developing NAFLD.

Abdominal Fat

People who have increased abdominal fat or higher waist circumference are at higher risk of developing NAFLD.

Age

People in their 40s and 50s who are at high risk of heart disease, are at higher risk of developing NAFLD.

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Avoid heavy alcohol consumption as it can cause damage to the liver.
  2. Have a balanced diet with low levels of saturated and trans fats (baked goods, sugary food, margarine, processed food) and simple sugars. Having a healthy weight can help reduce your risk of developing NAFLD.
  3. Avoid food with high saturated and trans fat content, so that you can maintain a healthy levels of triglyceride in your blood.

Exercise Recommendations:

  1. Keep a healthy lifestyle by doing regular exercises. Some examples are: 150 minutes of moderate intensity exercise (brisk walking, easy jogging, gardening ) per week, 75 minutes of vigorous intensity exercise (running, swimming, cycling) per week, or muscle strengthening (lifting weights, working with resistance bands) exercises twice per week.
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If you think you have the symptoms, consult with a healthcare professional.