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Health Risks Non-Alcoholic Fatty Liver Disease

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Based on your genetics, your genetic predisposition for Non-Alcoholic Fatty Liver Disease is

Normal
43.54
0%
25.5
76.5
100%

What does this mean?

 Your genotypes indicate that you have a typical risk for non-alcoholic fatty liver disease (NAFLD). Maintain a health diet and lifestyle to prevent NAFLD.

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How Is Your Genetic Risk Calculated?

Your genetic risk assessment is

43.54

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Non-Alcoholic Fatty Liver Disease.

Genes
Your Genotype
What it means?
Genes: KLF6
Your Genotype: GG
What it means? Increased risk
Genes: SOD2
Your Genotype: TT
What it means? Increased risk
Genes: PNPLA3
Your Genotype: CG
What it means? Increased risk
!

Limitations

This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Non-Alcoholic Fatty Liver Disease?

Non‐alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. NAFLD refers to the accumulation of excessive fats in liver cells, a condition known as steatosis and it is not due to excess alcohol consumption.

The prevalence of NAFLD is up to 30% in developed countries and nearly 10% in developing nations, making NAFLD the most common liver condition in the world.

NAFLD is strongly associated a with a number of metabolic risk factors including increased abdominal fat, poor ability of the body to use the hormone insulin or a condition better known as insulin resistance, high blood pressure and high blood levels of triglycerides, a type of fat and most significantly, obesity.

Over time, some people in these conditions (obesity, metabolic syndrome) can develop inflammation (swelling) of the liver. In some people, this inflammation can cause injury to the liver cell resulting in scarring of the liver tissue. Over years as more and more scar tissue begins building up, the liver will begin to harden a condition known as cirrhosis. This is considered a severe stage of the disease and it will only progress further causing liver failure or it increases the risk of developing liver cancer (Hepatocellular Carcinoma).

How It Affects Your Body

NAFLD is strongly associated with a number of metabolic risk factors including increased abdominal fat, poor ability of the body to use the hormone insulin (i.e. a condition better known as insulin resistance), high blood pressure, and high blood levels of triglycerides (a type of fat) and most significantly, obesity.

Over time, some people in these conditions (obesity, metabolic syndrome) can develop inflammation (swelling) of the liver. In some people, this inflammation can cause injury to the liver cells, resulting in scarring of the liver tissue.

Over the years, as more and more scar tissue begins building up, the liver will begin to harden, leading to a condition known as cirrhosis. This is considered a severe stage of the disease and it will only progress further, causing liver failure or increasing the risk of developing liver cancer (Hepatocellular Carcinoma).

Symptoms

Risk Factors Can Influence The Risk of Developing Non-alcoholic fatty liver disease

Genetics are NOT the only risk factor for Non-Alcoholic Fatty Liver Disease.
Non-Alcoholic Fatty Liver Disease is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.
The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Non-Alcoholic Fatty Liver Disease.

Triglyceride & Cholesterol Level

Having high triglyceride & cholesterol levels in the blood increases the risk of developing NAFLD.

Diabetes

Prediabetes and type 2 diabetes have been shown to increase the progression of NAFLD and liver inflammation.

Blood Pressure

Having high blood pressure increases the risk of developing NAFLD.

Abdominal Fat

People who have increased abdominal fat or higher waist circumference are at higher risk of developing NAFLD.

Age

People in their 40s and 50s who are at high risk of heart disease, are at higher risk of developing NAFLD.

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Increase consumption of whole grains, walnuts, avocado, and other polyunsaturated fats rich food. Have a balanced diet with low levels of saturated and trans fats (baked goods, sugary food, margarine, processed food), and simple sugars. Having a healthy weight can help reduce your risk of developing NAFLD.
  2. Avoid food with high saturated and trans fat content, so that you can maintain healthy levels of triglyceride in your blood. Food rich in saturated and trans fats are red meat, processed meat, and pastry.
  3. Increase intake of omega-3 rich food such as fish, and nuts. Omega-3 is a potent anti-inflammatory agent that can reduce possible liver damage from inflammation.
  4. Green tea and coffee have been found to boost liver function and weight management. Have at least 1 serving of coffee and 2 servings of green tea daily.
  5. Increase garlic intake. Garlic consumption has been found to improve body composition and weight-loss.

Lifestyle Recommendations:

  1. Maintain a healthy weight. Overweight and obese individuals have a higher risk to develop NAFLD.
  2. Avoid alcoholic beverages. Alcohol can damage liver cells and function, further increasing the risk of NAFLD development.
  3. Stop smoking. Smoking increases oxidative stress which can cause further vascular damage.

Exercise Recommendations:

  1. Incorporate 30-60 minutes of moderate-intensity exercise at least 5 times a week. Brisk walks, jogging, and cycling are great aerobic exercises.
  2. Incorporate resistance training at least 3 times a week. This includes swimming, weightlifting, and boxing.
  3. Aim to improve body composition with the goal of increasing muscle mass and reducing body fat percentage.

Result Explanation Recommendations:

  1. Follow a regular weekly exercise routine with at least 150 minutes of moderate intensity exercises (e.g. brisk walking, dancing, gardening) or 75 minutes of vigorous intensity exercises (e.g. running, swimming, cycling).
  2. Get a companion and an accountability partner to encourage each other for regular exercising.
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