Health Risks Type 2 Diabetes

Based on your genetics, your genetic predisposition for Type 2 Diabetes is

Normal
6.06
0%
1.53
19.43
100%

What does this mean?

 Your genotypes indicate that you have normal risk for Type 2 Diabetes.

How Is Your Genetic Risk Calculated?

Your genetic risk assessment is

6.06

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Type 2 Diabetes.

Genes
Your Genotype
What it means?
Genes: Intergenic
Your Genotype: CC
What it means? Increased risk
Genes: IL6
Your Genotype: GG
What it means? Increased risk
Genes: SLC30A8
Your Genotype: TT
What it means? Typical
Genes: PPARG_exon4
Your Genotype: CC
What it means? Increased risk
Genes: CDKN2A/2B_upstream
Your Genotype: CT
What it means? Increased risk
Genes: IGF2BP2_intron2.1
Your Genotype: GG
What it means? Typical
Genes: IGF2BP2_intron2.2
Your Genotype: AA
What it means? Typical
Genes: CDKAL1_intron5.4
Your Genotype: AG
What it means? Increased risk
Genes: TCF7L2_intron3.2
Your Genotype: CC
What it means? Typical
Genes: TCF7L2_intron4
Your Genotype: GG
What it means? Typical
Genes: HHEX_intergenic2
Your Genotype: AA
What it means? Typical
Genes: HHEX_intergenic1
Your Genotype: CT
What it means? Increased risk
Genes: TCF7L2_intron3.1
Your Genotype: AA
What it means? Typical
Genes: CDKAL1_intron5.3
Your Genotype: CG
What it means? Increased risk
Genes: CDKAL1_intron5.1
Your Genotype: AG
What it means? Increased risk
Genes: CDKAL1_intron5.2
Your Genotype: AC
What it means? Increased risk
Genes: Intergenic
Your Genotype: AC
What it means? Increased risk
Genes: FTO_intron1.4
Your Genotype: CC
What it means? Typical
Genes: PPARG_intron
Your Genotype: CG
What it means? Increased risk
Genes: KCNJ11
Your Genotype: CC
What it means? Typical
!

Limitations

This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Type 2 Diabetes?

Type 2 Diabetes Mellitus (DM) is characterized by high blood sugar (hyperglycemia), insulin resistance, and relative insulin deficiency. In type 2 DM, it becomes increasingly difficult for the body's cells to absorb and use the insulin effectively.

The severity of diabetes can vary quite a bit: Some people only need to make minor changes to their lifestyle such as maintain healthy weight and perform more exercise to manage their diabetes. However, some people who have type 2 diabetes would require long-term treatment that involves taking tablets or insulin. This type of DM is primarily due to the interaction between genetics and lifestyle factors.

How it can affect you?

Hormone insulin (produced by the pancreas) regulates the movement of sugar into the body's cells to be used as energy. After you eat, your blood sugar level rises, and insulin is released to keep the blood sugar level within the normal range.

However, insulin resistance or Type 2 DM happens when the pancreases produces enough insulin, however the body does not respond to insulin. At first to compensate this, the pancreas continues making more insulin pushing the cells to take up glucose and maintaining a normal blood sugar level.

Unfortunately, at later stages as the condition of the insulin resistance gets worse, the pancreas may no longer produce enough insulin. This causes the blood sugar levels to rise, and eventually leading to Type-2 DM.

The excess blood sugar in diabetes patients can cause health complications. It can severely damage the eyes, kidneys, nerves, and other body parts and doubles the risk of heart attack and stroke.

Do you have symptoms of type 2 diabetes?

Risk Factors Can Influence The Risk of Developing Type 2 diabetes

Genetics are NOT the only risk factor for Type 2 Diabetes.
Type 2 Diabetes is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.
The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Type 2 Diabetes.

History of Gestational Diabetes

Have a history of gestational diabetes or gave birth to a baby weighing 4kg or more, is one of the risk factors for type 2 diabetes.

Cholesterol Levels

Risk of developing type 2 diabetes increases in individuals who have a low level of HDL (good) cholesterol, or a high level of triglycerides.

Family History

Individuals with more than one relative with diabetes or with younger maternal diagnosis had even higher risk of developing type 2 diabetes.

Age

The risk of type 2 diabetes increases as you get older, especially after age 45.

Weight

You are more likely to develop type 2 diabetes if you are are overweight or obese.

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Aim to have an enriching diet with higher cereal fiber and low in calories, for example whole grains, fruits and vegetables.
  2. Consume carbohydrates with a low or medium Glycemic Index (GI). Carbohydrate can raise blood sugar. Glycemic index (GI), indicates how quickly the carbohydrate present in the food can raise blood sugar levels. Food with high GI causes your blood sugar levels to spike up much faster, as compared to food with medium or low GI. The body will breakdown low GI food slowly, resulting in a slower increase in the glucose level in the blood. Low GI food falls in between the ranks of 0 to 55. Moderate GI food range from 56 to 69 and anything higher than 69 is considered food with high GI. Typically low and moderate GI food are dried beans, kidney beans, barley , quinoa, fruits, greens, non-starchy vegetables, brown rice, pita bread.
  3. Cut down processed foods which are high in sodium (canned food, fast food, fried food), added sugar ( baked good, sweetened beverages) and saturated fats (red meat, butter, cheese). Stick with whole, fresh and minimally processed foods.
  4. Frequent, small meals can help to slow down the absorption of food, decrease blood sugar levels after meals and reduced insulin requirement during the course of the day.
  5. Reduce consumption of calorie-rich foods as they increase the risk of developing insulin resistance (IR) and subsequently diabetes.

Lifestyle Recommendations:

  1. Do not smoke as smoking is associated with insulin resistance, inflammation and dyslipidemia (high level of cholesterol and fats in the bloodstream). Studies shown that smoking increases the risk of the developing of diabetes.

Exercise Recommendations:

  1. Aim to have at least 150 min/week of moderate-intensity aerobic physical activity (50-70% of maximum heart rate), spread over at least 3 days/week, with no more than 2 consecutive days without exercise. Moderate-intensity aerobic are activities that will increase your heart rate. Example of these activities are: 2.5 miles of brisk walking, aerobic dancing , jogging.
  2. In the absence of contraindications, adults with type 2 diabetes should be encouraged to perform resistance training at least twice per week. Resistance training improves muscle strength and includes training using weights such as weight machines, and free weights.
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