Health Risks Gout

Based on your genetics, your genetic predisposition for Gout is

Normal
6.88
0%
5.7
8.77
100%

What does this mean?

 Your genotypes indicate that you have normal risk for Gout.

How Is Your Genetic Risk Calculated?

Your genetic risk assessment is

6.88

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Gout.

Genes
Your Genotype
What it means?
Genes: GCKR_exon15
Your Genotype: CT
What it means? Increased risk
Genes: ABCG2
Your Genotype: TG
What it means? Increased risk of gout
!

Limitations

This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Gout?

Gout is a form of arthritis caused by high levels of uric acid in the bloodstream. The excess uric acid forms needle-like crystals (urate) in the joints, which accumulates and causes inflammation in the joints. This can cause sudden and severe pain, swellings and redness.

Multiple genetic variations, each with a small effect, likely combine to increase the risk of developing gout. Most of the known genes play a role in transporting urate. Many gout-associated genes play a role in releasing urate into the urine if levels are too high or reabsorbing it back into the bloodstream if more is needed in the body. Other associated genes are involved in transporting or breaking down sugars or transporting other small molecules.

How does gout affect you?

When the body breaks down purines (found in food), uric acid is formed. It will be eliminated by the kidney as urine. In some cases, the body overproduces uric acid or makes normal amount, however the kidney is unable to efficiently eliminate it from the body. There will be high levels of uric acid in the body, which leads to the formation of crystals. Over time, the joint space can be irreversibly damaged, leading to chronic pain and disability with grossly deformed joints.

Symptoms of gout

Risk Factors Can Influence The Risk of Developing Gout

Genetics are NOT the only risk factor for Gout.
Gout is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.
The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Gout.

Alcohol

Having excessive alcohol use increases the risk of developing gout.

Weight

Being overweight and obese increases the risk of developing gout.

Diet

Having a diet high in certain high-purine foods increases the risk of developing gout.

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Folate intake and coffee consumption can reduce the risk of gout.
  2. Having high consumption of meat, seafood, food high in fructose (sugar) and sweetened soft drink can increase the risk of gout.
  3. Look into avoiding/reducing food with high levels of purines (which will be broken down and contribute to high levels of uric acid). Some examples of high purine food are meat (liver and kidney) and seafood (anchovies and sardine).
  4. Consumption of vegetables and low-fat or non-fat dairy products may help to reduce the frequency of flareups in gout.
  5. Reducing alcohol consumption can help reduce the risk of developing gout.
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If you think you have the symptoms, consult with a healthcare professional.