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Health Risks Gout

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Based on your genetics, your genetic predisposition for Gout is

Normal
6.88
0%
5.7
8.77
100%

What does this mean?

 Your genotypes indicate that you have a typical risk for gout. You are recommended to maintain a healthy diet and lifestyle.

Read more

How Is Your Genetic Risk Calculated?

Your genetic risk assessment is

6.88

This result is based on the SNPs(single nucleotide polymorphism)that are associated with Gout.

Genes
Your Genotype
What it means?
Genes: ABCG2
Your Genotype: TG
What it means? Increased risk of gout
Genes: GCKR_exon15
Your Genotype: CT
What it means? Increased risk
!

Limitations

This report does not diagnose any health conditions or provide medical advice. This should not be used as a diagnostic tool.
This result is limited to existing scientific research.
Please consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

What is Gout?

Gout is a form of arthritis caused by high levels of uric acid in the bloodstream. The excess uric acid forms needle-like crystals (urate) in the joints, which accumulates and causes inflammation in the joints. This can cause sudden and severe pain, swellings and redness.

Multiple genetic variations, each with a small effect, likely combine to increase the risk of developing gout. Most of the known genes play a role in transporting urate. Many gout-associated genes play a role in releasing urate into the urine if levels are too high or reabsorbing it back into the bloodstream if more is needed in the body. Other associated genes are involved in transporting or breaking down sugars or transporting other small molecules.

How It Affects Your Body

When the body breaks down purines (found in food), uric acid is formed. It will be eliminated by the kidney as urine.

In some cases, the body overproduces uric acid or makes a normal amount, however, the kidney is unable to efficiently eliminate it from the body. There will be high levels of uric acid in the body, which leads to the formation of crystals. Intreated, the joint space can be irreversibly damaged, leading to chronic pain and disability with grossly deformed joints.

Symptoms

Risk Factors Can Influence The Risk of Developing Gout

Genetics are NOT the only risk factor for Gout.
Gout is believed to be caused by a combination of environmental, genetic and lifestyle factors. Now that you have learnt about your genetic risk, you can determine how aggressively you need to make lifestyle changes to reduce your risk.
The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Gout.

Alcohol

High alcohol consumption has been associated with increased gout risk. This could be due to reduced and impaired purine metabolism, and excretion.

Obesity

Overweight and obese individuals have been found to be at higher risk of developing gout.

Diet

A high intake of purine-rich food such as seafood has been shown to increase gout risk. This is due to the increased intake and circulation of purines in the blood.

Family History

Gout has been found to be heritable due to various genetic factors that affect purine metabolism and excretion.

Suggested Lifestyle Changes

Dietary Recommendations:

  1. Avoid high consumption of meat, seafood, food high in fructose (sugar), and sweetened soft drinks as they can increase the risk of gout.
  2. Avoid or reduce consumption of food with high levels of purines. Some examples of high purine food are meat (liver and kidney) and seafood (anchovies and sardine).
  3. Reducing alcohol consumption can help reduce the risk of developing gout.

Result Explanation Recommendations:

  1. Do more physical activity as the body will respond by up-regulating glucose control.
  2. Incorporate 30 - 45 minutes of resistance training at least 3 times a week. Some examples are weightlifting, swimming, and bodyweight exercises.
  3. Incorporate 20 - 40 minutes of moderate-intensity aerobic exercises at least 5 times a week. Some examples are running, cycling, and competitive sports.
  4. Consult a physical trainer to ensure proper training technique and intensity is achieved.
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